Curriculum Vitae

Michael W. Bradbury, Ph.D.

Bradbury Medical Education Consulting

197 Los Gatos Place, Kissimmee, FL  34759

e-mail: mbradbury@bradmeded.com

Employment:

Consultant and Proprietor, Bradbury Medical Education Consulting, 7/2024 to present

Chair of Biochemistry, A. T. Still University - Kirksville College of Osteopathic Medicine, 6/18 to 6/22

Professor of Biochemistry, A. T. Still University - Kirksville College of Osteopathic Medicine, 6/18 to 6/2024

Chair of Basic Sciences Department, California Northstate University College of Medicine, 5/16 to 5/18

Professor of Biochemistry, Molecular Biology, and Genetics, California Northstate College of Medicine, Elk Grove, CA, 8/15 to 5/18

Professor of Biochemistry and Genetics, Alabama College of Osteopathic Medicine, Dothan, AL, 2/13 to 8/15

Associate Professor Biochemistry and Medical Genetics, Lake Erie College of Osteopathic Medicine, Erie, PA, 7/08 to 2/13

Assistant Professor of Biochemistry and Medical Genetics, Lake Erie College of Osteopathic Medicine, Erie, PA, 7/04 to 6/08

Consultant, Dept. of Medicine, Mt. Sinai Medical School, New York, NY, 7/03 to 6/04

Assistant Professor, Dept. of Medicine, Mt. Sinai Medical School, New York, NY, 8/99 to 6/03

Molecular Biologist, Dept. of Medicine, Mt. Sinai Medical School, New York, NY, 1/93 to 7/99

Instructor, Dept. of OBS/GYN, Mt. Sinai Medical School, New York, NY 1/88 to 12/92

Scientist, Biosyne Corporation, Houston, TX, 10/84 to 12/87

Postdoctoral Fellowship, NRSA Training Grant, UC Davis, 2/82 to 7/84

Education:

Ph. D., Biology, Yale University, New Haven, CT, 5/82. 
Thesis title: Primary Sex Determination and Gonadal Morphogenesis in the Mouse 
(Thesis advisor – Clement L. Markert, PhD)

M. Phil., Biology, Yale University, New Haven, CT, 5/79.

B. S., Biology, (Highest Honors), Rochester Institute of Technology, Rochester, NY, 6/76

 

Professional Activities:

Associate Editor for Reproductive Biology, Journal of Experimental Zoology, 4/91 to 3/06

Assistant Director of the Problem-Based Learning Pathway, Lake Erie College of Osteopathic Medicine, Erie, PA, 1/09 to 2/13

Director of Biochemistry, Lake Erie College of Osteopathic Medicine, Erie, PA, 4/10 to 2/13

Assistant Director of Research, Lake Erie College of Osteopathic Medicine, Erie, PA, 7/07 to 2/13

Intern/Resident Research Coordinator, Millcreek Community Hospital, 2007 to 2009

Director of Molecular Medicine course, ACOM, 5/13 to 8/14

Reviewer for Medical Science Educator, 2014 - 2022

Ad hoc reviewer for Hepatology, American Journal of Physiology, Diabetologia, Future Lipidology, MedSci Monitor, Molecular Biology Reports

Ad hoc Grant Reviewer – Israel Science Foundation

Item Writer for COMLEX Level 1, 2005 to present

COMLEX Level 1 Item Review committee, 2007, 2009, 2010, 2014, 2016, 2019 

COMLEX Level 1Exam Review committee, 2019

Attended COMLEX Item Writers Workshops, 2012, 2013 and 2018

Treasurer for Northwestern Pennsylvania Chapter of Sigma Xi, 2006-2011

      Organized speaker for Sigma Xi Distinguished Lecture series at LECOM, Oct. 5, 2006

Chair of the LECOM Institutional Animal Care and Use Committee (IACUC), 2009- 2013

Alternate member, LECOM Institutional Review Board (IRB), 2012 -2013

NBOME Contract Item Writer, 2013 and 2015

Member of NBOME National Faculty, Department of Foundational Biomedical Sciences, Division of Biochemistry, 2013 – present

NBOME Foundational Biosciences COMAT Development sessions, 2015 - 2019

MedU Science (now Aquifer Science), Discipline Team Leader for Genetics, 2014 

Annual Program Committee Member, IAMSE Conference for 2017

Session Chair, IAMSE 2017 Conference, IAMSE 2019 Conference, IAMSE 2023 Conference

LCME Self-Study Task Force Member for Provisional Accreditation, CNUCOM, 2017

Facilitator for the Basic Reviewer Training Workshop, 2022 and the Advanced Reviewer Training Workshop for Medical Science Educator, 2022, 2023, 2024

Associate Editor for Medical Science Educator, 2022 – present

COMLEX 1 Form Reviewer for NBOME, 2023

Teaching Experience:

Teaching Assistant (RIT)

            Comparative Vertebrate Anatomy Lab, Fall 1974, and Winter 1976

 

Teaching Assistant (Yale)

            Cell Biology Lab, Spring 1977

            Biology and Human Affairs, Fall 1977

            Biology of Reproduction Lab, Spring 1978

 

Laboratory Instructor (UCD)

            Graduate Lab in Embryo Physiology and Manipulation, Spring 1984

Assistant/Associate Professor (LECOM)

      Biochemistry (team taught), Fall 2004 to 2013

       Medical Genetics, Spring 2005 to 2013

       Module Director for Medical Genetics, Independent Study Program, 2005 to 2013

            Biochemistry lectures, Post Baccalaureate Program, Fall 2004 to 2012

            Facilitator, Problem Based Learning pathway, Fall 2005 to 2013

          Module Director for Medical Genetics, Primary Care Scholars Pathway, 2008 to 2013

          Module Director for Biochemistry in the Independent Study Program, Fall 2010 to 2012

Professor (ACOM)

Biochemistry and Genetics in Molecular Medicine and Systems courses, 2013 – 2015

Co-course Director, Molecular Medicine, Fall 2013

Professor (CNUCOM)

Biochemistry and Genetics in various courses, 2015 – 2018

Course Director, Renal System, Fall 2016 

Course Director, Student Self-Directed Scholarly Project, 2017

Professor (ATSU-COM)

Biochemistry and Genetics in various courses, 2018 – present

Course Director, Medical Genetics and Embryology, 2020 – 2023

Publications:

Carter, ML, Bradbury MW, 2016. Oxygen Isotope Ratios in Primate Bone Carbonate Reflect Amount of Leaves and Vertical Stratification in the Diet. Am. J. Primatol., 78:1086-1097 (doi:10.1002/ajp.22432)

Bradbury MW, Stump D, Guarnieri F, Berk PD, 2011. Molecular modeling and confirmation of a predicted fatty acid binding site of mitochondrial aspartate aminotransferase. J. Mol. Biol., 412:412-422 (doi:10.1016/j.jmb.2011.07.034)

Rogers RW, Tranovich MJ, Bradbury MW, Habusta SF, 2011. Foot Deformities and Pain in the Geriatric Patient, J Penn Osteopathic Med Assoc, 55, No. 4:15-20

Petrescu O, Cheema AF, Fan X, Bradbury MW, Berk PD, 2008. Differences in Adipocyte Uptake of Long Chain Fatty Acids in Response to High Fat Diets in Osborne-Mendel and S5B/Pl Rats. Int J Obes 32: 853-862 (doi:10.1038/sj.ijo.0803792)

Bradbury MW, 2006. Lipid Metabolism and Liver Inflammation. I. Hepatic Fatty Acid Uptake: Possible Role in Steatosis. Am. J. Physiol. Gastrointest. Liver Physiol. 290:G194-8.

Berk, PD, Zhou, SL, Bradbury, MW, 2005. Increased hepatocellular uptake of long chain fatty acids occurs by different mechanisms in fatty livers due to obesity or excess ethanol use, contributing to development of steatohepatitis in both settings. Transact Amer Clin Climatolog Assoc 116:335-345.

Petrescu O, Fan X, Gentileschi P, Hossain S, Bradbury M, Gagner M, Berk PD, 2005. Long chain fatty acid uptake is upregulated in omental adipocytes from patients undergoing bariatric surgery for obesity. Int. J. Obes. Relat. Metab.Disord. 29:196-203

Bradbury MW, Berk PD, 2004. Lipid metabolism in hepatic steatosis. Clinics. Liver Dis. 8:639-671

Bradbury, MW, Berk,PD, 2004. Cellular uptake of long chain free fatty acids: the structure and function of plasma membrane fatty acid binding protein. Adv.Mol.Cell Biol. 33:47-81.

Fan X, Bradbury MW, Berk PD, 2003. Leptin and insulin modulate nutrient partitioning and weight loss in ob/ob mice through regulation of long-chain fatty acid uptake by adipocytes. J. Nutrition 133:2707-2715.

Bradbury, MW and PD Berk, 2000. Mitochondrial aspartate aminotransferase: direction of a single protein with two distinct functions to two sub-cellular sites does not require alternative splicing of the mRNA. Biochem. J. 345:423-427

Berk PD, Zhou S, Kiang C, Stump DD, Fan X, Bradbury MW, 1999. Selective up-regulation of fatty acid uptake by adipocytes characterizes both genetic and diet-induced obesity in rodents. J.Biol.Chem. 274:28626-28631.

Zhou, S-L, RE Gordon, M Bradbury, D Stump, C-L Kiang and PD Berk, 1998. Ethanol up-regulates fatty acid uptake and plasma membrane expression and export of mitochondrial aspartate aminotransferase in HepG2 cells. Hepatology 27:1067-1074.

Berk, PD, S-L Zhou, M Bradbury, D Stump, C-L Kiang, and LM Isola, 1997. Regulated membrane transport of free fatty acids in adipocytes: Role in obesity and non-insulin dependent diabetes mellitus. Trans. Amer. Clin. Climat Assoc. 108:26-43.

Berk, PD, S-L Zhou, C-L Kiang, D Stump, M Bradbury, and LM Isola, 1997. Uptake of long chain free fatty acids is selectively upregulated in adipocytes of Zucker rats with genetic obesity and non-insulin dependent diabetes mellitus. J. Biol. Chem. 272:8830-8835.

Berk, PD, S-L Zhou, M Bradbury, D Stump, C-L Kiang, and N-I Han, 1996. Crigler-Najjar Syndrome and the jaundiced Gunn rat: Model diseases for the evaluation of novel molecular and cellular therapies. In: HE Blum, GY Yu and CH Wu, editors, Molecular Diagnosis and Gene Therapy. Kluwer, Lancaster (UK). pp 223-244.

Berk, PD, M Bradbury, S-L Zhou, D Stump and N-I Han, 1996. Characterization of membrane transport processes: Lessons from the study of BSP, bilirubin and fatty acid uptake. Seminars in Liver Diseases 16:107-120.

Isola, LM, S-L Zhou, C-L Kiang, DD Stump, MW Bradbury and PD Berk, 1995. 3T3 fibroblasts transfected with a cDNA for mitochondrial aspartate aminotransferase express plasma membrane fatty acid-binding protein and saturable fatty acid uptake. PNAS 92:9866-9870

Fabricant JD, Chalmers JH Jr., Bradbury MW, 1995. Bioluminescent Strains of E. coli for the Assay of Biocides. Bull. Environ. Contam. Toxicol. 54:90-95

Gordon, JW and MW Bradbury, 1991. Genomic imprinting - a phenomenon with implications for micromanipulation-assisted IVF. J. IVF & Emb. Trans. 8:5-14

Gordon JW, Isola LM, Bradbury MW, 1990. Rapid Sexing of Preimplantation Mouse Embryos by Blastomere Biopsy and Enzymatic Amplification, Advances in Assisted Reproductive Technologies, pp 871-886

Bradbury, MW, L Isola and J Gordon, 1990. Enzymatic amplification of a Y-chromosome repeat in a single blastomere allows identification of the sex of preimplantation mouse embryos. PNAS 87:4053-4057

Bradbury, MW and JD Fabricant, 1988. Changes in melanin granules caused by coat color mutations in the fox. J. Hered. 79:133-136

Chalmers, JH, Jr., MW Bradbury, and JD Fabricant, 1987. A multicolored luminol-based chemiluminescnce demonstration. J. Chem. Ed. 64:969-970

Bradbury, MW, 1987. Testes of XX ↔ XY chimeric mice develop from fetal ovotestes. Dev. Genet. 8:207-218.

Bradbury, MW, 1983. Functional capacity of Sex-reversed (XX, Sxr/+) mouse germ cells as shown by progeny derived from a female chimera. J. Exp. Zool. 266:315-320

Abstracts:

Bradbury, MW, 2019. Algorithms and Assumptions Dilute DNA Database Information Integrity, KCOM IBRS poster.

Bradbury, MW, Sheffield M, 2019. From the Basic Concept of pH to Complex Acid-Base Disorders in Two Hours Using Self-Directed Learning, IAMSE conference

Bradbury, MW, Sheffield M, 2019. From the Basic Concept of pH to Complex Acid-Base Disorders in Two Hours Using Self-Directed Learning, ABE conference

Bradbury, MW, K Riggs, E Hengstebeck, 2015. Integrating Basic and Clinical Sciences Using an Exercise Aimed at Eliciting Family History from Standardized Patients, IAMSE conference

Hernandez, M, M Robinson, B Kessler, M Bradbury, 2015. Reflections on the First Academic School Year of a New Medical School, IAMSE conference

Fulton, T, M Bradbury, M Dell, B Dickinson, A Edmondson, S Everse, J Fishback, E Gallman, D Harris, J Jones, V Lyons, J Nixon, A Paganini, A Poznanski, D Russo, J Szarek, A Wilson-Delfosse, L Fall, 2015. Unpacking your brain: collaborative identification of core basic science concepts important in clinical decision-making, IAMSE conference

Bradbury, MW, 2014. Implementing active learning at a new medical school and student response to different learning formats, IAMSE conference

Peterson, HL, A Hudder, MW Bradbury, 2013. The effects of excess fructose, glucose, and xylose on lipogenic gene expression and fat accumulation of HuH-7 hepatoma cells in long-term culture. LECOM Research Day

Ogg, R, DO, S Habusta, N Grimm, M Bradbury, 2012. The Effect of Racquet Head Size on Overuse Shoulder Injuries in Competitive Tennis Players.  LECOM Research Day

Bradbury, MW, C Church and R Pratt, 2011. Chronic Exposure of HuH7 Hepatoma Cells to Ethanol Causes Increased Fatty Acid Uptake, Which is Reversed by Withdrawal. LECOM Research Day 

Bradbury, MW, S Woodward, R Pratt, 2011. Role of Mitochondrial Leader Sequence and Mature Protein Sequence on Subcellular Localization of Mitochondrial Aspartate Aminotransferase. LECOM Research Day 

Evanoff-Jurkovic, M, M Bradbury, J Eysamen, L Epperly, 2011. Does pelvic/sacral somatic dysfunction affect the Galleazzi Test? LECOM Research Day, Oral Presentation

Stefanko, JJ, JL Williams, MW Bradbury, SF Habusta, 2010. Direct Pressure Measurements of Vertebroplasty vs Kyphoplasty: Cadaveric Study, LECOM Research Day

Bradbury, MW, R Pratt, 2009. Chronic Ethanol Exposure Reversibly Increases Fatty Acid Uptake in HuH7 Hepatoma Cells. LECOM Research Day

Bradbury, MW, 2008. Identifying Early Indicators of Performance on COMLEX 1, AACOM Meeting

Dunn, P, R Pratt, MW Bradbury, 2008.Assessment of Predicted Structure-Function Relationship in a Fatty Acid Binding Protein, LECOM Research Day 

Pratt, R, E Adewale, MW Bradbury, 2007. Targeting a Mitochondrial Enzyme to the Secretory Pathway by Leader Sequence Exchange. LECOM Research Day and TREC Research Day 

Servin-Obert, S, R Pratt and MW Bradbury, 2006. Reporter Construct Analysis of the Mitochondrial Aspartate Aminotransferase Promoter. LECOM Research Day

Berk P, Petrescu O, Bradbury M, 2004. Different responses of Osborne-Mendel and S5B/Pl rats to high fat diets, Obesity Research 12, A141-A141

Petrescu, O, X Fan, MW Bradbury, PD Berk, 2003. Selective regulation of long chain fatty acid uptake across adipocyte plasma membranes is a control point for body adiposity. Gastroenterology 124, Suppl 1:A70

Bradbury, MW, O Petrescu, PD Berk, 2002. Identification of mitochondrial aspartate aminotransferase in a population of small vesicles just beneath the plasma membrane in HuH7 cells. Hepatol. 36:239A

Bradbury, MW, X Fan, PD Berk, 2000. Transcriptional control of the mitochondrial aspartate aminotransferase gene in a model of alcoholic liver disease. Hepatol. 32:331A

Fan, X, MW Bradbury, DD Stump, PD Berk, 2000. Leptin Infusion Downregulates Long Chain Free Fatty Acid Uptake in ob/ob Mouse Adipocytes. Obes. Res. 8, Suppl 1:PA17 

Bradbury, MW, X Fan, PD Berk, 2000. Up-regulation of a fatty acid transporter in adipocyte differentiation and alcoholic fatty liver. Devel. Biol. 222:275

 Bradbury, M, S-L Zhou, DD Stump, PD Berk, 1999. Differing Effects of a High Fat Diet on Adipocyte Oleic Acid Uptake in S5b/PL and Osborne-Mendel Rats, Physiological Genomics and Rat Models, Cold Spring Harbor.

Berk, PD, DD Stump, X Fan, MW Bradbury, 1999. Cellular uptake of long chain free fatty acids occurs by two distinct processes: Facilitated transport and passive diffusion. Hepatol. 30:462A

Bradbury, MW, L Delavega, RL Stockert, PD Berk, 1998. Green fluorescent protein-tagged mitochondrial aspartate aminotransferase illustrates the intracellular sorting of the native enzyme. Hepatol. 28:511A

Zhou, S-L, C-L Kiang, M Bradbury, E Albanis, MI Fiel, PD Berk, 1997. Increased hepatocellular fatty acid uptake in fatty livers due to EtOH abuse but not those due to obesity. Hepatol. 26:254A

Zhou, S-L, R Gordon, C-L Kiang, DD Stump, M Bradbury, LM Isola, PD Berk, 1996. Intracellular movement and cellular export of mitochondrial aspartate aminotransferase from hepatoma cell lines. Hepatol. 24:128A

Zhou, S-L, C-L Kiang, M Bradbury, L Isola, DD Stump, PD Berk, 1995. Up-regulation of mitochondrial aspartate aminotransferase mRNA parallels fatty acid uptake in 3T3-L1 cells and adipocytes from obese and diabetic rats. Hepatol. 22:313A

Zhou, S-L, C-L Kiang, M Bradbury, R Gordon, DD Stump, N-I Han, PD Berk, 1995. Effects of EtOH on mitochondrial aspartate aminotransferase expression and cellular leakage and fatty acid uptake in HepG2 cells. Hepatol. 22:241A

Zhou, S-L, M Bradbury, C-L Kiang, LM Isola, PD Berk, 1994. 3T3 fibroblasts transfected with aspartate aminotransferase cDNAs encoding mutated or deleted mitochondrial leaders fail to exhibit increased fatty acid uptake. Hepatol. 20:174A

Isola, L, L Glass, MW Bradbury, and J Gordon, 1989. Rapid and efficient cloning of DNA flanking foreign genes inserted in transgenic mice using polymerase chain reaction. Blood 74:99A 

Gordon, JW, LM Isola, and MW Bradbury, 1989. Rapid determination of sex in preimplantation mouse embryos by blastomere biopsy and enzymatic amplification. Proc. Soc. Gyn. Invest. 36:1 

Fabricant, JD, LC Nuti, BS Minhas, WC Baker, JS Capehart, P Marrack, JH Chalmers, Jr., MW Bradbury, and JE Womack, 1987. Gene transfer in goats. Theriogenology 27:229 

White, KL, MW Bradbury, GB Anderson, and RH BonDurant, 1984. Immunofluorescent detection of a male-specific factor on preimplantation bovine embryos. Theriogen. 21:275 

Oral Presentations:

Cork D, Mamoag L, Bradbury M, 2023, Modelling Early Gene Expression Changes in Alcoholic Fatty Liver Disease, IBRS, Kirksville, MO

Bradbury, MW, 2015. The role of free fatty acids in the increase in fatty liver disease. Ninety-second Annual Meeting of the Alabama Academy of Science, Inc., Livingston, AL

Bradbury, MW, 2014. Challenges and Obstacles: ACOM, presented as part of a Focus Session on Challenges and Obstacles for the First Year of a New Medical School at the Annual IAMSE conference

Bradbury, MW, X Fan, DD Stump, JA Odin, F Guarnieri, PD Berk, 2001. Mapping the fatty acid binding site in hepatic fatty acid binding protein with molecular mapping and mutagenesis. Hepatol. 34:256A 

Bradbury, MW, Berk PD, 1997. Sequence divergence of mouse mitochondrial aspartate aminotransferase isozymes, 9th International Conference on Genes, Gen Families and Isozymes 

Bradbury, MW, 1981. Coat Color Genetics of the Mouse, Western Connecticut State College 

Invited Talks:

Genomics in Cancer and Medical Disease, keynote for UPMC Hamot Research Day, Erie, PA, April 2016

Hepatic Fatty Acid Uptake: Possible Role in Steatosis, presented at EB 2006, in the American Physiological Society Special Topic Symposium on Lipid Metabolism and Liver Inflammation, April 2, 2006

Funding:

Principal investigator, Warner Fermaturo and The ATSU Board of Trustees Research Grant. Cell culture model of progression and resolution of alcoholic liver disease Funded for the period 07/01/2022 to 6/30/2024

Principal investigator, CNUCOM mini-grant. Fatty acid uptake in obesity and hepatic steatosis. Funded for the period 01/01/2018 to 12/31/2018

Principal investigator, CNUCOM mini-grant. Modulation of Hepatoma Gene Expression Patterns by Substrate and Culture Conditions: A Model for Hepatocyte Response to Environmental Conditions. Funded for the period 01/01/2017 to 12/31/2017

Principal investigator, ABMRF grant. Locating ethanol responsive regions in the aspartate aminotransferase promoter. Funded for the period 01/01/2006 to 12/31/2007

Co-investigator, NIH grant # 5 RO1 DK52401-02. Facilitated uptake of long chain fatty acids in obesity. Principal Investigator, PD Berk. Funded for the period 01/01/98 to 12/31/02 

Co-investigator, NIH grant # 1 RO1 HD25136-01A1. Rapid prenatal sexing of cleaving mouse embryos. Principal Investigator, J Gordon. Funded for the period 09/30/89 to 08/31/92

Certifications and Training:

Medical Education Research Certificate, AAMC Group on Educational Affairs, 2014

Organizational Leadership in Academic Medicine: 2016 Executive Development Seminar for Associate Deans and Department Chairs, Englewood, CO.

Awards:

Albert Nelson Marquis Lifetime Achievement Award, 2022

Member of inaugural class of the Distinguished Reviewer Panel for Medical Science Educator, 2020

Reviewer of the Year Award, Medical Science Educator, 2020

LECOM Research Day Poster Award, 3rd place, 2013

Best Abstract, Society for Gynecological Investigation, 1989

National Science Foundation Predoctoral Fellowship, 1976-1979

National Merit Scholarship, Rochester Institute of Technology, 1972-1976

Identifiers on Research Sites Online

ORCID: 0000-0002-6384-2681

Researcher ID: G-5002-2013

Scopus Author ID: 7103022883 

Google Scholar: https://scholar.google.com/citations?hl=en&user=JU5FFKsAAAAJ

Professional Societies:

American Association for the Advancement of Science

Association of Medical and Graduate Departments of Biochemistry

International Association of Medical Science Educators

Sigma Xi